FITC标记的脑特异性多肽蛋白19抗体
产品名称： FITC标记的脑特异性多肽蛋白19抗体
英文名称： Anti-PCP4/FITC
产品编号： HZ-11326R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCP4/FITC Conjugated antibody
FITC标记的脑特异性多肽蛋白19抗体
| 产品编号 | bs-11326R-FITC |
| 英文名称 | Anti-PCP4/FITC |
| 中文名称 | FITC标记的脑特异性多肽蛋白19抗体 |
| 别 名 | Brain specific antigen PCP 4; Brain specific polypeptide PEP 19; Brain specific polypeptide PEP19; PEP19; Purkinje cell protein 4; PCP-4; PCP4_HUMAN; PEP-19. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 7kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCP4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PCP-4 is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome. Function: Probable regulator of calmodulin signaling. Subunit: Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater. Similarity: Belongs to the PCP4 family. Contains 1 IQ domain. Database links: Entrez Gene: 5121 Human Entrez Gene: 18546 Mouse Entrez Gene: 25510 Rat Omim: 601629 Human SwissProt: P48539 Human SwissProt: P63054 Mouse SwissProt: P63055 Rat Unigene: 80296 Human Unigene: 5023 Mouse Unigene: 9736 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
| PCP－4是钙调素（CAM）调节蛋白，在神经元细胞中高度表达。通过其IQ基序，PCP4介导CaM的钙依赖结合特性和钙从CaM的C-末端结构域的结合和解离率。IQ基序含有丝氨酸残基，其可由蛋白激酶C（PKC）的所有亚型磷酸化。PCP－4与子宫肌瘤、神经退行性疾病如阿尔茨海默病和亨廷顿氏病有关。此外，PCP－4的过度表达被认为在小脑发育不良中起作用，这是唐氏综合征的一个关键特征。 |