FITC标记的转录因子蛋白SIM1抗体
产品名称： FITC标记的转录因子蛋白SIM1抗体
英文名称： Anti-SIM1/FITC
产品编号： HZ-20462R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SIM1/FITC Conjugated antibody
FITC标记的转录因子蛋白SIM1抗体
| 英文名称 | Anti-SIM1/FITC |
| 中文名称 | FITC标记的转录因子蛋白SIM1抗体 |
| 别 名 | bHLHe14; Class E basic helix-loop-helix protein 14; SIM1; SIM1_HUMAN; Single minded homolog 1; Single-minded homolog 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 85kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SIM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors. Several PAS domain family members have been identified including AhR, Arnt 1, and single-minded proteins (SIM1 and SIM2). The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand-dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element. Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, thus inhibiting transcriptional activation. The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, which is located on chromosome 21, is a candidate for the gene responsible for Down syndrome. Function: Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT. Subcellular Location: Nucleus. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. Contains 1 Single-minded C-terminal domain. Database links: Entrez Gene: 6492 Human Entrez Gene: 20464 Mouse Entrez Gene: 309888 Rat Omim: 603128 Human SwissProt: P81133 Human SwissProt: Q61045 Mouse Unigene: 520293 Human Unigene: 4774 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Per-Arnt-Sim(PAS)结构域被鉴定为介导各种PAS家族转录因子之间关联的270个氨基酸基序。已经鉴定出几个PAS结构域家族成员，包括AhR、Arnt 1和单心蛋白（SIM1和SIM2）。芳香（芳基）烃受体AhR是一种配体依赖性转录因子，与称为异源应答元件（XREs）的特定DNA序列相互作用，激活包括CYP1A1、谷胱甘肽S-转移酶Ya亚基和DT-黄递酶在内的多种基因。Ah受体核转运蛋白1(Arnt 1)是Ah受体的配体依赖性核转运所必需的，也是Ah受体与XRE元件结合所必需的。SIM1和SIM2均抑制AHR/ARNT二聚，从而抑制转录激活。SIM基因被认为参与发育过程中组织的引导和分区，位于染色体21的SIM2基因是唐氏综合征相关基因的候选基因。