FITC标记的通用转录因子ⅡA亚基2抗体
产品名称： FITC标记的通用转录因子ⅡA亚基2抗体
英文名称： Anti-GTF2A2/FITC
产品编号： HZ-16347R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-GTF2A2/FITC Conjugated antibody
FITC标记的通用转录因子ⅡA亚基2抗体
| 英文名称 | Anti-GTF2A2/FITC |
| 中文名称 | FITC标记的通用转录因子ⅡA亚基2抗体 |
| 别 名 | General transcription factor IIA; General transcription factor IIA subunit 2; General transcription factor IIA, 2 (12kD subunit); General transcription factor IIA, 2, 12kDa; gtf2a2; HsT18745; T2AG_HUMAN; TF2A2; TFIIA 12; TFIIA; TFIIA gamma; TFIIA p12 subunit; TFIIA-12; TFIIA-gamma; TFIIA12; TFIIAS; Transcription initiation factor IIA gamma chain; Transcription initiation factor IIA subunit 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 12kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GTF2A2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008] Function: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Subcellular Location: Nucleus. Similarity: Belongs to the TFIIA subunit 2 family. Database links: Entrez Gene: 2958 Human Entrez Gene: 235459 Mouse Entrez Gene: 100365822 Rat Entrez Gene: 83828 Rat Omim: 600519 Human SwissProt: P52657 Human SwissProt: Q80ZM7 Mouse SwissProt: Q90YG6 Rainbow Trout SwissProt: O08950 Rat Unigene: 512934 Human Unigene: 293117 Mouse Unigene: 4053 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
含TATA的II类基因的精确转录起始涉及RNA聚合酶II（POLR2A；MIM 180660）和一般起始因子TFIIA、TFIIB（MIM18963）、TFIID（MIM13650）、TFIIE（MIM18962）、TFIIF（MIM18968）、TFIIG/TFIIJ和TFIIH（MIM18972）的有序组装。第一步包括由TATA结合亚基(TBP；MIM 600075)识别TATA元素，并且可以由TFIIA调节，TFIIA是与TBP和TBP相关因子(TAF；MIM 600475)相互作用的因子。TFIIa在酵母中有2个亚基（43和12 kD），在高等真核生物中有3个亚基。在HeLa提取物中，它由35kDα亚基和19kDβ亚基组成，分别由GTF2A1(MIM 600520)的N端和C端区域编码，以及由GTF2A2编码的12kD伽马亚基(DeJong等人，1995[PubMed 7724559])。