H-1152 dihydrochloride | MedChemExpress (MCE)-产品咨询-资讯-生物在线

H-1152 dihydrochloride | MedChemExpress (MCE)

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H-1152 dihydrochloride

CAS No. : 871543-07-6

MCE 国际站:H-1152 dihydrochloride

产品活性:H-1152 dihydrochloride 是一种膜通透的,选择性的 ROCK 抑制剂,Ki 值为 1.6 nM,对 ROCK2IC50 值为 12 nM。

研究领域:Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Cytoskeleton  |  TGF-beta/Smad

作用靶点:ROCK

In Vitro: H-1152 dihydrochloride is an inhibitor of Rho-kinase, with an IC50 of 12 nM for ROCK2. H-1152 (H-1152P) also shows less inhibitory activities against CaMKII, PKG, AuroraA, PKA, Src, PKC, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 0.180, 0.360, 0.745, 3.03, 3.06, 5.68, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively.
H-1152 potently inhibits Rho kinase, with a Ki of 1.6 nM, and slightly suppresses PKA, PKC and MLCK, with Kis of 0.63, 9.27, and 10.1 μM, respectively. H-1152 (0.1-10 μM) highly inhibits MARCKS phosphorylation, with an IC50 value of 2.5 μM in LPA-treated cells, but shows no such obvious effects in PDBu-treated cells.
H-1152 (0.5-10 μM) cuases no decreased neuronal survival. H-1152 (1, 5 or 10 μM) also exerts no alterations in the ratios of different neuronal morphologies. Furthermore, H-1152 (10 μM) increases neurite length in both BMP4 and LIF cultures.

相关产品:Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Cytoskeleton Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Serine/Threonine Kinase Inhibitor Library  |  Extracellular Vesicles (EVs) Compound Library  |  Multi-Target Compound Library  |  Bioactive Compound Library Max  |  Y-27632  |  Chroman 1  |  Belumosudil  |  Fasudil Hydrochloride  |  Thiazovivin  |  Narciclasine  |  Afuresertib  |  GSK269962A  |  Ripasudil  |  GSK429286A  |  Y-33075  |  CCG-222740  |  Pentanoic acid  |  ROCK inhibitor-2  |  CMPD101  |  AT13148  |  HA-100  |  Zelasudil  |  SAR407899  |  SR-3677  |  GSK180736A  |  RKI-1447  |  LX7101  |  CRT0066854  |  H-1152  |  Netarsudil hydrochloride

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