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Cabergoline

CAS No. : 81409-90-7

MCE 国际站：Cabergoline

产品活性：Cabergoline 是一种麦角衍生的多巴胺 D₂ 亚类受体激动剂，高亲和力作用于 D₂，D₃ 和 5-HT_2B 受体，K_i 分别为 0.7，1.5 和 1.2。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Autophagy

作用靶点：Dopamine Receptor  |  Autophagy

In Vitro: Cabergoline acts as a potent agonist of D₂, D₃ and 5-HT_2B receptors. Pretreatment with Cabergoline inhibits H₂O₂-induced neuronal cell death in a dose-dependent manner. In the following experiments, 10 μM of Cabergoline is used to investigate its neuroprotective effects. MAP2 staining reveals that Cabergoline significantly suppresses the loss of neurons caused by H₂O₂ incubation. The detection of apoptotic nuclear condensation suggested that Cabergoline prevents apoptotic cell death following H₂O₂ exposure.

In Vivo: The most significant reduction in rapid eye movement (REM) sleep bout number occurred during the light phase, in which Cabergoline-injected female handled mice has 67.3% less REM sleep bouts (F_(1,11)=12.892, P=0.004), although the greatest number in reduction of REM sleep bouts occurr during the dark phase (82.3% fewer REM sleep bouts; F_(1,11)=3.667, P=0.082). In male mice, Cabergoline reduces baseline Prolactin (PRL) levels (98.5%; F_(1,6)=13.192, P=0.011) from 5.8±1.3 to 0.08 ng/mL within 2 hours of injection. After a 7-day recovery period, PRL levels return to values that are not different from baseline (5.0±0.60 ng/mL; F_(1,6)=0.715, P=0.43).

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